Ten peptides. Evidence tiers. Safety profiles. Legal status. Everything you need to make an informed decision — in one scannable chart.
How to read this chart — Evidence tiers
Preview — 3 of 10 peptides
Melanocortin receptor agonist — also known as Vyleesi®
The only FDA-approved peptide specifically for hypoactive sexual desire disorder (HSDD) in premenopausal women. Works centrally via the brain's melanocortin system — not through hormones. Also used off-label in men for libido and erectile function.
Glutathione precursor — decades of clinical use
One of the most researched antioxidant compounds in medicine, used since the 1960s as an acetaminophen overdose treatment and mucolytic. Replenishes intracellular glutathione, reduces oxidative stress, and has emerging evidence in OCD, addiction recovery, and liver protection.
Glycyl-L-histidyl-L-lysine copper complex
A naturally occurring copper-binding peptide that declines with age. Topically, it's one of the best-evidenced anti-aging ingredients — stimulating collagen synthesis, reducing inflammation, and improving skin density. Systemic injectable use is emerging but less studied.
Full matrix — all 10 peptides
Zadaxin® — approved in 35+ countries
A 28-amino-acid thymic peptide that acts as a precision modulator of the immune system — amplifying response when it's suppressed (chronic infection, cancer) and dampening it when overactive (autoimmune flares). Approved as Zadaxin® in over 35 countries; used off-label in the US by functional medicine practitioners.
The body's master antioxidant tripeptide (γ-Glu-Cys-Gly)
The most abundant intracellular antioxidant, critical for detoxification, immune function, and skin brightness. Oral bioavailability is limited; liposomal oral and IV/IM routes show better efficacy. Widely used in functional medicine for oxidative stress, liver support, and skin-lightening protocols.
15-mer peptide derived from gastric juice protein
Arguably the most researched "biohacking" peptide, with an extraordinary pre-clinical record across tendon repair, gut healing, ligament regeneration, and neuroprotection. The gap: nearly all evidence is rodent studies. No completed Phase II human trials exist. The science is compelling enough to warrant interest — and honest about its limits.
Synthetic analog of the actin-binding protein Tβ4
TB-500 is the active fragment of Thymosin Beta-4, a protein that promotes cell migration, blood vessel formation, and tissue repair. Often "stacked" with BPC-157 for injury recovery protocols. Small cardiac trials show promise for heart failure; broader human evidence remains limited.
GHRH analog + GHRP — often combined in one injection
The most popular growth hormone secretagogue combination. CJC-1295 extends the half-life of growth hormone-releasing hormone; Ipamorelin selectively stimulates GH release without major cortisol or appetite spikes. Typically used for body composition, sleep quality, and longevity protocols by functional medicine doctors. No FDA-approved human indication.
Heptapeptide anxiolytic — registered in Russia as Selank®
A synthetic analog of the immune peptide tuftsin. Developed by the Russian Institute of Molecular Genetics, registered as an anxiolytic nasal spray in Russia. Shows anxiolytic and nootropic effects without the dependency or sedation of benzodiazepines. US clinical trial data is sparse; most evidence is from Russian literature and small human studies.
Tetrapeptide — Ala-Glu-Asp-Gly
A synthetic tetrapeptide derived from the pineal gland extract Epithalamin. The most intriguing longevity compound on this list — Russian studies report telomerase activation, extended lifespan in animal models, improved melatonin secretion, and cancer-inhibiting effects. The data is genuinely interesting; the source (primarily Russian, 1980s–2000s) requires cautious interpretation until replicated independently.
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