SS-31 (Elamipretide): The Mitochondrial Inner Membrane Peptide

SS-31 (Elamipretide) is a precision mitochondrial peptide that targets cardiolipin on the inner mitochondrial membrane — the only compound known to reach and stabilize this specific architecture at therapeutic concentrations. Phase II human trials in heart failure (HFpEF) and Barth syndrome have earned FDA Breakthrough Therapy Designation and Fast Track Designation.

The clinical significance: mitochondrial dysfunction is upstream of nearly every age-related disease. SS-31 addresses the problem at the source rather than managing downstream symptoms.

For the full research breakdown including mechanism, dosing, and human trial data, see SS-31: Why This Mitochondrial Peptide Matters for Everyone →